Hormones

SHBG

Sex Hormone-Binding Globulin (SHBG) regulates the availability of sex hormones like testosterone and estrogen.

What it is

Sex Hormone-Binding Globulin (SHBG) regulates the availability of sex hormones like testosterone and estrogen. High SHBG can lower free testosterone, leading to reduced libido, muscle loss, and fatigue. Low SHBG may increase free testosterone, potentially causing hormonal imbalances like insulin resistance or PCOS. Monitoring SHBG helps assess hormone balance, metabolic health, and reproductive function, ensuring optimal energy levels, mood stability, and overall well-being.

What affects your levels

High SHBG is often caused by liver disease, hyperthyroidism, excessive alcohol intake, or high estrogen levels. Low SHBG may result from insulin resistance, obesity, hypothyroidism, or high androgen levels. Chronic inflammation, poor diet, and hormonal imbalances also contribute to fluctuations. Identifying and addressing underlying causes helps regulate SHBG levels, optimizing hormone function for metabolism, energy production, and reproductive health.

Signs and symptoms

High SHBG can cause low libido, fatigue, muscle loss, and difficulty gaining strength. Low SHBG may lead to acne, excess hair growth (in women), insulin resistance, and metabolic issues. Chronic imbalances can affect reproductive health, mood, and body composition. Regular hormone monitoring, a nutrient-rich diet, and lifestyle adjustments help regulate SHBG, maintaining optimal hormone function and overall health.

Foods that help

For low SHBG, fiber-rich foods like flaxseeds, whole grains, and cruciferous vegetables help improve hormone metabolism. Anti-inflammatory foods such as fatty fish, avocados, and nuts support SHBG balance. For high SHBG, lean proteins, zinc-rich foods like shellfish, and vitamin D sources like eggs and dairy help maintain healthy testosterone levels. A balanced diet with whole foods ensures proper SHBG regulation, preventing hormonal imbalances.

Foods to limit

For high SHBG, excessive alcohol, refined carbohydrates, and ultra-processed foods may elevate levels further. For low SHBG, high-sugar foods, trans fats, and excessive dairy may contribute to insulin resistance, worsening imbalances. Reducing these dietary stressors and focusing on nutrient-dense foods supports proper hormone regulation, optimizing SHBG levels for balanced testosterone and estrogen activity.

Educational information only — not a diagnosis. Every Pheno result is interpreted in context and reviewed by a physician.

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