SII integrates three immune compartments — platelets (thromboinflammation), neutrophils (innate activation), and lymphocytes (adaptive capacity) — into a single index.
SII integrates three immune compartments — platelets (thromboinflammation), neutrophils (innate activation), and lymphocytes (adaptive capacity) — into a single index. Elevated SII is linked to higher cardiovascular mortality, cancer incidence, and accelerated biological aging in large cohort studies.
Same drivers as NLR/PLR combined: chronic stress, obesity, autoimmune disease, smoking, malignancy, infection, corticosteroids.
Asymptomatic. Very high values reflect severe immunoinflammatory dysregulation that may co-occur with fatigue, recurrent infection, or slow recovery.
See NLR. Comprehensive anti-inflammatory lifestyle: Mediterranean diet, omega-3, adequate sleep, stress management, regular exercise.
See NLR.
Educational information only — not a diagnosis. Every Pheno result is interpreted in context and reviewed by a physician.
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