HOMA-IR is the most widely validated non-invasive measure of insulin resistance.
HOMA-IR is the most widely validated non-invasive measure of insulin resistance. Even mildly elevated values (>2.0) predict future type 2 diabetes, cardiovascular disease, fatty liver disease, and accelerated biological aging years before clinical symptoms.
Excess visceral fat, inactivity, refined carbohydrates, poor sleep, chronic stress, hormonal conditions (PCOS, hypothyroidism, Cushing's), corticosteroids and antipsychotics. Unexpectedly low HOMA-IR warrants investigation of inadequate insulin production.
Fatigue after meals, difficulty losing weight, sugar cravings, brain fog, central weight gain, skin tags, acanthosis nigricans. Long-term: pre-diabetes, metabolic syndrome, fatty liver.
High-fibre legumes, oats, non-starchy vegetables slow insulin demand. Lean protein, olive oil, avocado, nuts, fatty fish, fermented foods. Vinegar with meals reduces postprandial insulin.
Refined carbohydrates, sugary beverages, trans fats, excess alcohol, processed meats.
Educational information only — not a diagnosis. Every Pheno result is interpreted in context and reviewed by a physician.
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